Integrative Biology

The study of multifactorial and complex interactions in human diseases has been transformed by the omics revolution. The speed and scale of omics analysis have increased exponentially in the past decades, and it is now easier and faster to generate large amounts of biological data. However, extracting meaningful information from this “sea of data” remains a major challenge. The field of integrative biology utilizes a holistic approach to integrate multilayer biological data. Integrative biology is a promising approach for the study of a wide range of human diseases.

Lista de serviços

Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells.
Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells.
RNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma.
RNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma.
MicroRNA Transcriptome Profiling in Heart of Trypanosoma cruzi-Infected Mice: Parasitological and Cardiological Outcomes.
MicroRNA Transcriptome Profiling in Heart of Trypanosoma cruzi-Infected Mice: Parasitological and Cardiological Outcomes.
Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription.
Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription.
Antimicrobial peptide LL-37 participates in the transcriptional regulation of melanoma cells.
Antimicrobial peptide LL-37 participates in the transcriptional regulation of melanoma cells.
Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer.
Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer.
Integration of miRNA and gene expression profiles suggest a role for miRNAs in the pathobiological processes of acute Trypanosoma cruzi infection.
Integration of miRNA and gene expression profiles suggest a role for miRNAs in the pathobiological processes of acute Trypanosoma cruzi infection.
Integrative Biology Approaches Applied to Human Diseases
Integrative Biology Approaches Applied to Human Diseases
Proteomics reveals disturbances in the immune response and energy metabolism of monocytes from patients with septic shock.
Proteomics reveals disturbances in the immune response and energy metabolism of monocytes from patients with septic shock.
Genomics, epigenomics and pharmacogenomics of Familial Hypercholesterolemia (FHBGEP): A study protocol.
Genomics, epigenomics and pharmacogenomics of Familial Hypercholesterolemia (FHBGEP): A study protocol.
Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers
Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers
Profiling plasma-extracellular vesicle proteins and microRNAs in diabetes onset in middle-aged male participants in the ELSA-Brasil study.
Profiling plasma-extracellular vesicle proteins and microRNAs in diabetes onset in middle-aged male participants in the ELSA-Brasil study.
Big Data and machine learning in cancer theranostics
Big Data and machine learning in cancer theranostics
Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci.
Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci.
Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID-19 severity
Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID-19 severity