CSBL publications

Lista de serviços

• Morphological, cellular, and molecular basis of brain infection in COVID-19 patients 2022
  PNAS Morphological, cellular, and molecular basis of brain infection in COVID-19 patients
• C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps 2023
  JCI C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps
• Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation 2022
  Cell Reports Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation
• Ten quick tips for harnessing the power of ChatGPT in computational biology 2023
  PLOS Computational Biology Ten quick tips for harnessing the power of ChatGPT in computational biology
• Characteristics and anatomic location of PD-1(+)TCF1(+) stem-like CD8 T cells in chronic viral infection and cancer 2023
  PNAS Characteristics and anatomic location of PD-1(+)TCF1(+) stem-like CD8 T cells in chronic viral infection and cancer
• COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis 2023
  PNAS COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis
• Transcriptomic signatures induced by the Ebola virus vaccine rVSV-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study 2022
  The Lancet Microbe Transcriptomic signatures induced by the Ebola virus vaccine rVSV-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study
• Hidden in plain sight: uncovering the role of CREB1 in HIV-1 vaccine-induced immunity 2021
  Nature immunology Hidden in plain sight: uncovering the role of CREB1 in HIV-1 vaccine-induced immunity
• Inflammation induced by influenza virus impairs human innate immune control of pneumococcus. 2018
  Nature immunology Inflammation induced by influenza virus impairs human innate immune control of pneumococcus.
• Metabolic Phenotypes of Response to Vaccination in Humans. 2017
  Cell Metabolic Phenotypes of Response to Vaccination in Humans.
• Long non-coding RNAs associated with infection and vaccine-induced immunity 2021
  Essays in Biochemistry Long non-coding RNAs associated with infection and vaccine-induced immunity
• Molecular alterations in the extracellular matrix in the brains of newborns with congenital Zika syndrome. 2020
  Science signaling Molecular alterations in the extracellular matrix in the brains of newborns with congenital Zika syndrome.
• Sepsis expands a CD39(+) plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity 2021
  Immunity Sepsis expands a CD39(+) plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity
• Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination. 2019
  PNAS Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination.
• Systems analysis of subjects acutely infected with the Chikungunya virus. 2019
  PLoS pathogens Systems analysis of subjects acutely infected with the Chikungunya virus.
• Network vaccinology. 2020
  Seminars in immunology Network vaccinology.
• Evolution and epidemic spread of SARS-CoV-2 in Brazil. 2020
  Science Evolution and epidemic spread of SARS-CoV-2 in Brazil.
• Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis. 2020
  Cell metabolism Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis.
• The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. 2016
  Nature The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation.
• Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. 2016
  Nature Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy.
• Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. 2014
  Science Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation.
• Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination. 2016
  Nature immunology Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination.
• Programming the magnitude and persistence of antibody responses with innate immunity. 2011
  Nature Programming the magnitude and persistence of antibody responses with innate immunity.
• Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. 2017
  Nature microbiology Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.
• Molecular signatures of antibody responses derived from a systems biology study of five human vaccines. 2014
  Nature immunology Molecular signatures of antibody responses derived from a systems biology study of five human vaccines.
• Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures. 2015
  Immunity Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures.
• Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. 2010
  Science Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine.
• Prior upregulation of interferon pathways in the nasopharynx impacts viral shedding following live attenuated influenza vaccine challenge in children 2022
  Cell Reports Medicine Prior upregulation of interferon pathways in the nasopharynx impacts viral shedding following live attenuated influenza vaccine challenge in children
• TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination. 2014
  Immunity TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination.
• Systems biology of vaccination for seasonal influenza in humans. 2011
  Nature immunology Systems biology of vaccination for seasonal influenza in humans.
• Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity. 2013
  Immunity Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity.
• The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. 2010
  Nature immunology The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.
• PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical beta-coronavirus disease 2022
  Science advances PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical beta-coronavirus disease
• Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. 2009
  Nature immunology Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans.
• Systems vaccinology. 2010
  Immunity Systems vaccinology.
• Knockout of cellular prion protein in glioblastoma affects the expression of Wnt signaling genes 2022
  Cancer Research Knockout of cellular prion protein in glioblastoma affects the expression of Wnt signaling genes
• PD-1/PD-L1 inhibition enhances chemotherapy-induced neuropathic pain by suppressing neuroimmune antinociceptive signaling 2022
  Cancer Immunology Research PD-1/PD-L1 inhibition enhances chemotherapy-induced neuropathic pain by suppressing neuroimmune antinociceptive signaling
• Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study. 2018
  The Lancet. Infectious diseases Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study.
• MS-Driven Metabolic Alterations Are Recapitulated in iPSC-Derived Astrocytes 2022
  Annals of Neurology MS-Driven Metabolic Alterations Are Recapitulated in iPSC-Derived Astrocytes
• Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression 2022
  Angiogenesis Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression
• Aryl hydrocarbon receptor (AhR) activation contributes to high fat diet induced vascular dysfunction 2022
  British Journal of Pharmacology Aryl hydrocarbon receptor (AhR) activation contributes to high fat diet induced vascular dysfunction
• Systems analysis of protective immune responses to RTS,S malaria vaccination in humans. 2017
  PNAS Systems analysis of protective immune responses to RTS,S malaria vaccination in humans.
• Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. 2018
  Nature communications Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
• Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis. 2018
  Nature communications Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis.
• Daily Rhythms of TNFα Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle. 2018
  Cell host & microbe Daily Rhythms of TNFα Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle.
• Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells 2022
  eLife Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells
• Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection. 2017
  eLife Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection.
• Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood. 2016
  PNAS Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood.
• Differentiation of Memory CD8 T Cells Unravel Gene Expression Pattern Common to Effector and Memory Precursors 2022
  Frontiers in Immunology Differentiation of Memory CD8 T Cells Unravel Gene Expression Pattern Common to Effector and Memory Precursors
• Insight Into the Long Noncoding RNA and mRNA Coexpression Profile in the Human Blood Transcriptome Upon Leishmania infantum Infection. 2022
  Frontiers in immunology Insight Into the Long Noncoding RNA and mRNA Coexpression Profile in the Human Blood Transcriptome Upon Leishmania infantum Infection.
• SARS-CoV-2 infected children form early immune memory responses dominated by nucleocapsid-specific CD8+ T cells and antibodies 2022
  Frontiers in Immunology SARS-CoV-2 infected children form early immune memory responses dominated by nucleocapsid-specific CD8+ T cells and antibodies
• Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination 2022
  Mucosal immunology Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination
• Initial viral load determines the magnitude of the human CD8 T cell response to yellow fever vaccination. 2015
  PNAS Initial viral load determines the magnitude of the human CD8 T cell response to yellow fever vaccination.
• Systems Biology Analysis of the Radiation-Attenuated Schistosome Vaccine Reveals a Role for Growth Factors in Protection and Hemostasis Inhibition in Parasite Survival. 2021
  Frontiers in immunology Systems Biology Analysis of the Radiation-Attenuated Schistosome Vaccine Reveals a Role for Growth Factors in Protection and Hemostasis Inhibition in Parasite Survival.
• Acute Inflammation Is a Predisposing Factor for Weight Gain and Insulin Resistance 2022
  Pharmaceutics Acute Inflammation Is a Predisposing Factor for Weight Gain and Insulin Resistance
• The evolution of knowledge on genes associated with human diseases 2022
  iScience The evolution of knowledge on genes associated with human diseases
• Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci. 2018
  Genome biology Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci.
• Flavivirus-Mediating B Cell Differentiation Into Antibody-Secreting Cells in Humans Is Associated With the Activation of the Tryptophan Metabolism. 2020
  Frontiers in immunology Flavivirus-Mediating B Cell Differentiation Into Antibody-Secreting Cells in Humans Is Associated With the Activation of the Tryptophan Metabolism.
• Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19 2022
  Blood advances Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19
• HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria 2022
  Scientific Reports HIV infection increases the risk of acquiring Plasmodium vivax malaria: a 4-year cohort study in the Brazilian Amazon HIV and risk of vivax malaria
• Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation. 2014
  Cell host & microbe Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation.
• Uptake of Plasmodium chabaudi hemozoin drives Kupffer cell death and fuels superinfections 2022
  Scientific Reports Uptake of Plasmodium chabaudi hemozoin drives Kupffer cell death and fuels superinfections
• Severe COVID-19 shares a common neutrophil activation signature with other acute inflammatory states 2022
  Cells Severe COVID-19 shares a common neutrophil activation signature with other acute inflammatory states
• Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate. 2019
  Frontiers in immunology Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate.
• Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses. 2019
  Frontiers in immunology Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses.
• Antisense intronic non-coding RNA levels correlate to the degree of tumor differentiation in prostate cancer. 2004
  Oncogene Antisense intronic non-coding RNA levels correlate to the degree of tumor differentiation in prostate cancer.
• Big Data and machine learning in cancer theranostics 2022
  Frontiers in Big Data Big Data and machine learning in cancer theranostics
• Acute Zika Virus Infection in an Endemic Area Shows Modest Proinflammatory Systemic Immunoactivation and Cytokine-Symptom Associations. 2018
  Frontiers in immunology Acute Zika Virus Infection in an Endemic Area Shows Modest Proinflammatory Systemic Immunoactivation and Cytokine-Symptom Associations.
• Automatic detection of the parasite Trypanosoma cruzi in blood smears using a machine learning approach applied to mobile phone images 2022
  PeerJ Automatic detection of the parasite Trypanosoma cruzi in blood smears using a machine learning approach applied to mobile phone images
• Tucuxi-BLAST: Enabling fast and accurate record linkage of large-scale health-related administrative databases through a DNA-encoded approach 2022
  PeerJ Tucuxi-BLAST: Enabling fast and accurate record linkage of large-scale health-related administrative databases through a DNA-encoded approach
• Lower temperatures reduce type I interferon activity and promote alphaviral arthritis. 2017
  PLoS pathogens Lower temperatures reduce type I interferon activity and promote alphaviral arthritis.
• Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates. 2012
  Blood Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates.
• Cross-sectional analysis of students and school workers reveals a high number of asymptomatic SARS-CoV-2 infections during school reopening in Brazilian cities 2022
  Heliyon Cross-sectional analysis of students and school workers reveals a high number of asymptomatic SARS-CoV-2 infections during school reopening in Brazilian cities
• Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever. 2017
  Frontiers in immunology Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever.
• Thinking out of the box: revisiting health surveillance based on medical records 2023
  Antimicrobial Stewardship & Healthcare Epidemiology Thinking out of the box: revisiting health surveillance based on medical records
• Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression 2023
  Angiogenesis Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression
• The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation. 2013
  PLoS genetics The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation.
• Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID-19 severity 2023
  Journal of Medical Virology Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID-19 severity
• S100A9 Drives the Chronification of Psoriasiform Inflammation by Inducing IL-23/Type 3 Immunity 2023
  Journal of Investigative Dermatology S100A9 Drives the Chronification of Psoriasiform Inflammation by Inducing IL-23/Type 3 Immunity
• CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation 2023
  The Journal of Infectious Diseases CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation
• Cutting Edge: Polycomb Repressive Complex 1 Subunit Cbx4 Positively Regulates Effector Responses in CD8 T Cells 2023
  Journal of Immunology Cutting Edge: Polycomb Repressive Complex 1 Subunit Cbx4 Positively Regulates Effector Responses in CD8 T Cells
• Transcriptome analysis of six tissues obtained post-mortem from sepsis patients 2023
  Journal of Cellular and Molecular Medicine Transcriptome analysis of six tissues obtained post-mortem from sepsis patients
• Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSVΔG-ZEBOV-GP 2023
  iScience Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSVΔG-ZEBOV-GP
• Imbalanced IL-1B and IL-18 Expression in Sézary Syndrome 2023
  International Journal of Molecular Sciences Imbalanced IL-1B and IL-18 Expression in Sézary Syndrome
• Identification of pathogenic variants in the Brazilian cohort with Familial hypercholesterolemia using exon-targeted gene sequencing 2023
  Gene Identification of pathogenic variants in the Brazilian cohort with Familial hypercholesterolemia using exon-targeted gene sequencing
• Novel therapeutic avenues for the study of chronic liver disease and regeneration: The foundation of the Iberoamerican Consortium for the study of liver Cirrhosis 2023
  Gastroenterology & Hepatology Novel therapeutic avenues for the study of chronic liver disease and regeneration: The foundation of the Iberoamerican Consortium for the study of liver Cirrhosis
• Chikungunya patient transcriptional signatures faithfully recapitulated in a C57BL/6J mouse model 2022
  Frontiers in immunology Chikungunya patient transcriptional signatures faithfully recapitulated in a C57BL/6J mouse model
• Immunodominant antibody responses directed to SARS-CoV-2 hotspot mutation sites and risk of immune escape 2023
  Frontiers in immunology Immunodominant antibody responses directed to SARS-CoV-2 hotspot mutation sites and risk of immune escape
• Baseline gene signatures of reactogenicity to Ebola vaccination: a machine learning approach across multiple cohorts 2023
  Frontiers in immunology Baseline gene signatures of reactogenicity to Ebola vaccination: a machine learning approach across multiple cohorts
• Expression of HMGCS2 in intestinal epithelial cells is downregulated in inflammatory bowel disease associated with endoplasmic reticulum stress 2023
  Frontiers in immunology Expression of HMGCS2 in intestinal epithelial cells is downregulated in inflammatory bowel disease associated with endoplasmic reticulum stress
• Comparative transcriptomic analysis of long noncoding RNAs in Leishmania-infected human macrophages 2023
  Frontiers in genetics Comparative transcriptomic analysis of long noncoding RNAs in Leishmania-infected human macrophages
• SARS-CoV-2 uses CD4 to infect T helper lymphocytes 2023
  eLife SARS-CoV-2 uses CD4 to infect T helper lymphocytes
• Combining IP(3) affinity chromatography and bioinformatics reveals a novel protein-IP(3) binding site on Plasmodium falciparum MDR1 transporter. 2022
  Current Research in Microbial Sciences Combining IP(3) affinity chromatography and bioinformatics reveals a novel protein-IP(3) binding site on Plasmodium falciparum MDR1 transporter.
• Increased mTOR Signaling and Impaired Autophagic Flux Are Hallmarks of SARS-CoV-2 Infection. 2022
  Current Issues in Molecular Biology Increased mTOR Signaling and Impaired Autophagic Flux Are Hallmarks of SARS-CoV-2 Infection.
• Antibody responses to recombinant vesicular stomatitis virus-Zaire Ebolavirus vaccination for Ebola virus disease across doses and continents: 5-year durability 2023
  Clinical Microbiology and Infection Antibody responses to recombinant vesicular stomatitis virus-Zaire Ebolavirus vaccination for Ebola virus disease across doses and continents: 5-year durability
• Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort 2023
  PLoS neglected tropical diseases Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort
• Gene Signatures of Symptomatic and Asymptomatic Clinical-Immunological Profiles of Human Infection by Leishmania (L.) chagasi in Amazonian Brazil 2023
  Microorganisms Gene Signatures of Symptomatic and Asymptomatic Clinical-Immunological Profiles of Human Infection by Leishmania (L.) chagasi in Amazonian Brazil
• Kdm6b Regulates the Generation of Effector CD8 + T Cells by Inducing Chromatin Accessibility in Effector-Associated Genes 2021
  Journal of Immunology Kdm6b Regulates the Generation of Effector CD8 + T Cells by Inducing Chromatin Accessibility in Effector-Associated Genes
• Colorimetric RT-LAMP SARS-CoV-2 diagnostic sensitivity relies on color interpretation and viral load 2021
  Scientific Reports Colorimetric RT-LAMP SARS-CoV-2 diagnostic sensitivity relies on color interpretation and viral load
• Profiling plasma-extracellular vesicle proteins and microRNAs in diabetes onset in middle-aged male participants in the ELSA-Brasil study. 2021
  Physiological reports Profiling plasma-extracellular vesicle proteins and microRNAs in diabetes onset in middle-aged male participants in the ELSA-Brasil study.
• Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers 2021
  Melatonin Research Melatonin-Index as a biomarker for predicting the distribution of presymptomatic and asymptomatic SARS-CoV-2 carriers
• Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine. 2021
  JCI insight Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine.
• In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19. 2021
  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19.
• An Experimental DUAL Model of Advanced Liver Damage 2021
  Hepatology Communication An Experimental DUAL Model of Advanced Liver Damage
• Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes. 2021
  European archives of psychiatry and clinical neuroscience Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes.
• Human Transcriptomic Response to the VSV-Vectored Ebola Vaccine. 2021
  Vaccines Human Transcriptomic Response to the VSV-Vectored Ebola Vaccine.
• Why should obese youth be prioritized in COVID-19 vaccination programs? A nationwide retrospective study 2022
  The Lancet Regional Health-Americas Why should obese youth be prioritized in COVID-19 vaccination programs? A nationwide retrospective study
• Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation. 2021
  Blood Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation.
• OUTBREAK: a user-friendly georeferencing online tool for disease surveillance. 2021
  Biological Research OUTBREAK: a user-friendly georeferencing online tool for disease surveillance.
• Gene profiling of Chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritis. 2012
  Arthritis and rheumatism Gene profiling of Chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritis.
• Biological sex influences antibody responses to routine vaccinations in the first year of life. 2020
  Acta paediatrica (Oslo, Norway : 1992) Biological sex influences antibody responses to routine vaccinations in the first year of life.
• Systems immunology of flavivirus infection. 2021
  Zika Virus Biology, Transmission, and Pathways Systems immunology of flavivirus infection.
• Zika virus infection and cytokines. 2021
  Zika Virus Biology, Transmission, and Pathways Zika virus infection and cytokines.
• Drug repositioning for psychiatric and neurological disorders through a network medicine approach. 2020
  Translational psychiatry Drug repositioning for psychiatric and neurological disorders through a network medicine approach.
• São Paulo School of Advanced Sciences on Vaccines: an overview. 2020
  The journal of venomous animals and toxins including tropical diseases São Paulo School of Advanced Sciences on Vaccines: an overview.
• ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19. 2020
  The Journal of Infectious Diseases ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19.
• Genomics, epigenomics and pharmacogenomics of Familial Hypercholesterolemia (FHBGEP): A study protocol. 2020
  The FHBGEP protocol has the potential to elucidate the genetic basis and molecular mechanisms involved in the pathophysiology of FH and PH, particularly in the Brazilian population. This pioneering approach includes genomic, epigenomic and functional studies, which results will contribute to the improvement of the diagnosis, prognosis and personalized therapy of FH patients. Genomics, epigenomics and pharmacogenomics of Familial Hypercholesterolemia (FHBGEP): A study protocol.
• Proteomics reveals disturbances in the immune response and energy metabolism of monocytes from patients with septic shock. 2021
  Scientific Reports Proteomics reveals disturbances in the immune response and energy metabolism of monocytes from patients with septic shock.
• miRNAs may play a major role in the control of gene expression in key pathobiological processes in Chagas disease cardiomyopathy. 2020
  PLoS neglected tropical diseases miRNAs may play a major role in the control of gene expression in key pathobiological processes in Chagas disease cardiomyopathy.
• Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria. 2020
  PLoS neglected tropical diseases Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria.
• Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination. 2020
  NPJ vaccines Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination.
• Network Medicine: Methods and Applications 2020
  Networks in Systems Biology Network Medicine: Methods and Applications
• Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses 2021
  Nature Communications Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses
• Whole-Genome Sequencing of Leishmania infantum chagasi Isolates from Honduras and Brazil 2021
  Microbiology Resource Announcements Whole-Genome Sequencing of Leishmania infantum chagasi Isolates from Honduras and Brazil
• Immature neutrophil signature associated with the sexual dimorphism of systemic juvenile idiopathic arthritis. 2020
  Journal of leukocyte biology Immature neutrophil signature associated with the sexual dimorphism of systemic juvenile idiopathic arthritis.
• The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age. 2021
  JCI Insight The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age.
• Neuroinflammation at single cell level: What is new? 2020
  Journal of Leukocyte Biology Neuroinflammation at single cell level: What is new?
• Antigenicity prediction and vaccine recommendation of human influenza virus A (H3N2) using convolutional neural networks. 2020
  Human vaccines & immunotherapeutics Antigenicity prediction and vaccine recommendation of human influenza virus A (H3N2) using convolutional neural networks.
• Methods for predicting vaccine immunogenicity and reactogenicity. 2020
  Human vaccines & immunotherapeutics Methods for predicting vaccine immunogenicity and reactogenicity.
• Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19 2021
  Frontiers in Medicine Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19
• Editorial: User-Friendly Tools Applied to Genetics or Systems Biology. 2020
  Frontiers in genetics Editorial: User-Friendly Tools Applied to Genetics or Systems Biology.
• P2x7 Receptor Signaling Blockade Reduces Lung Inflammation and Necrosis During Severe Experimental Tuberculosis. 2021
  Frontiers in Cellular and Infection Microbiology P2x7 Receptor Signaling Blockade Reduces Lung Inflammation and Necrosis During Severe Experimental Tuberculosis.
• Hydroquinone exposure alters the morphology of lymphoid organs in vaccinated C57Bl/6 mice. 2020
  Environmental pollution (Barking, Essex : 1987) Hydroquinone exposure alters the morphology of lymphoid organs in vaccinated C57Bl/6 mice.
• Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients 2021
  eLife Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients
• Variants in the Kisspeptin-GnRH Pathway Modulate the Hormonal Profile and Reproductive Outcomes. 2020
  DNA and cell biology Variants in the Kisspeptin-GnRH Pathway Modulate the Hormonal Profile and Reproductive Outcomes.
• Toward an Integrated View of Operational Tolerance in Human Renal Transplantation: A Systems Biology Perspective. 2020
  Critical reviews in immunology Toward an Integrated View of Operational Tolerance in Human Renal Transplantation: A Systems Biology Perspective.
• Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression, Shedding, and Antibody-dependent Enhancement (ADE). 2020
  Clinics (Sao Paulo, Brazil) Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression, Shedding, and Antibody-dependent Enhancement (ADE).
• Gene signatures of autopsy lungs from obese patients with COVID-19. 2021
  Clinical Nutrition ESPEN Gene signatures of autopsy lungs from obese patients with COVID-19.
• Noninvasive prenatal paternity determination using microhaplotypes: a pilot study. 2020
  BMC medical genomics Noninvasive prenatal paternity determination using microhaplotypes: a pilot study.
• webCEMiTool: Co-expression Modular Analysis Made Easy. 2019
  Frontiers in genetics webCEMiTool: Co-expression Modular Analysis Made Easy.
• Assessing the Impact of Sample Heterogeneity on Transcriptome Analysis of Human Diseases Using MDP Webtool. 2019
  Frontiers in genetics Assessing the Impact of Sample Heterogeneity on Transcriptome Analysis of Human Diseases Using MDP Webtool.
• Predicting RNA Families in Nucleotide Sequences Using StructRNAfinder. 2019
  Methods in molecular biology (Clifton, N.J.) Predicting RNA Families in Nucleotide Sequences Using StructRNAfinder.
• Molecular degree of perturbation of plasma inflammatory markers associated with tuberculosis reveals distinct disease profiles between Indian and Chinese populations. 2019
  Scientific reports Molecular degree of perturbation of plasma inflammatory markers associated with tuberculosis reveals distinct disease profiles between Indian and Chinese populations.
• SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages. 2019
  Scientific reports SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages.
• Integrative Biology Approaches Applied to Human Diseases 2019
  Computational Biology Integrative Biology Approaches Applied to Human Diseases
• StructRNAfinder: an automated pipeline and web server for RNA families prediction. 2018
  BMC bioinformatics StructRNAfinder: an automated pipeline and web server for RNA families prediction.
• CEMiTool: a Bioconductor package for performing comprehensive modular co-expression analyses. 2018
  BMC bioinformatics CEMiTool: a Bioconductor package for performing comprehensive modular co-expression analyses.
• In situ Immune Signatures and Microbial Load at the Nasopharyngeal Interface in Children With Acute Respiratory Infection 2018
  Frontiers in microbiology In situ Immune Signatures and Microbial Load at the Nasopharyngeal Interface in Children With Acute Respiratory Infection
• TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis. 2018
  Journal of autoimmunity TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis.
• Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2). 2018
  Malaria journal Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2).
• Gene regulatory and signaling networks exhibit distinct topological distributions of motifs. 2018
  Physical review. E Gene regulatory and signaling networks exhibit distinct topological distributions of motifs.
• Building capacity for advances in tuberculosis research; proceedings of the third RePORT international meeting. 2018
  Tuberculosis (Edinburgh, Scotland) Building capacity for advances in tuberculosis research; proceedings of the third RePORT international meeting.
• Systems Immunology 2018
  Theoretical and Applied Aspects of Systems Biology Systems Immunology
• Systems Vaccinology Applied to DNA Vaccines: Perspective and Challenges. 2017
  Current issues in molecular biology Systems Vaccinology Applied to DNA Vaccines: Perspective and Challenges.
• Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration. 2017
  Cell death & disease Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration.
• Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques. 2017
  Journal Article Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques.
• N-Methyl-d-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection 2017
  mBio N-Methyl-d-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection
• Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer. 2017
  Oncotarget Down-regulation of 14q32-encoded miRNAs and tumor suppressor role for miR-654-3p in papillary thyroid cancer.
• Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells. 2017
  Pharmacological research Toxicogenomic and bioinformatics platforms to identify key molecular mechanisms of a curcumin-analogue DM-1 toxicity in melanoma cells.
• Integration of miRNA and gene expression profiles suggest a role for miRNAs in the pathobiological processes of acute Trypanosoma cruzi infection. 2017
  Scientific reports Integration of miRNA and gene expression profiles suggest a role for miRNAs in the pathobiological processes of acute Trypanosoma cruzi infection.
• Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications. 2017
  Scientific reports Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications.
• Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular Dysfunction. 2017
  The Journal of Infectious Diseases Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular Dysfunction.
• Myeloperoxidase in human peripheral blood lymphocytes: Production and subcellular localization. 2016
  Cellular immunology Myeloperoxidase in human peripheral blood lymphocytes: Production and subcellular localization.
• Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription. 2007
  Genome biology Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription.
• Antimicrobial peptide LL-37 participates in the transcriptional regulation of melanoma cells. 2016
  Journal of Cancer Antimicrobial peptide LL-37 participates in the transcriptional regulation of melanoma cells.
• Analysis of LexA binding sites and transcriptomics in response to genotoxic stress in Leptospira interrogans. 2016
  Nucleic acids research Analysis of LexA binding sites and transcriptomics in response to genotoxic stress in Leptospira interrogans.
• SerpinB2 Deficiency Results in a Stratum Corneum Defect and Increased Sensitivity to Topically Applied Inflammatory Agents. 2016
  The American journal of pathology SerpinB2 Deficiency Results in a Stratum Corneum Defect and Increased Sensitivity to Topically Applied Inflammatory Agents.
• Systems vaccinology: Enabling rational vaccine design with systems biological approaches. 2015
  Vaccine Systems vaccinology: Enabling rational vaccine design with systems biological approaches.
• Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms. 2015
  PLoS neglected tropical diseases Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms.
• MicroRNA Transcriptome Profiling in Heart of Trypanosoma cruzi-Infected Mice: Parasitological and Cardiological Outcomes. 2015
  PLoS neglected tropical diseases MicroRNA Transcriptome Profiling in Heart of Trypanosoma cruzi-Infected Mice: Parasitological and Cardiological Outcomes.
• Vaccinology in the era of high-throughput biology. 2015
  Philosophical transactions of the Royal Society of London. Series B, Biological sciences Vaccinology in the era of high-throughput biology.
• RNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma. 2015
  Molecular and cellular biology RNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma.
• Is the gut microbiome key to modulating vaccine efficacy? 2015
  Expert review of vaccines Is the gut microbiome key to modulating vaccine efficacy?
• Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection. 2014
  PLoS neglected tropical diseases Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection.
• Chapter 15 - Systems Biology of Infectious Diseases and Vaccines 2014
  Computational Systems Biology Chapter 15 - Systems Biology of Infectious Diseases and Vaccines
• Genetic control of immune response and susceptibility to infectious diseases. 2014
  Editorial Genetic control of immune response and susceptibility to infectious diseases.
• Gene signatures related to B-cell proliferation predict influenza vaccine-induced antibody response. 2014
  European journal of immunology Gene signatures related to B-cell proliferation predict influenza vaccine-induced antibody response.
• CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis. 2014
  Journal of virology CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis.
• Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells. 2014
  PloS one Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells.
• The role of prophage in plant-pathogenic bacteria. 2013
  Annual review of phytopathology The role of prophage in plant-pathogenic bacteria.
• Systems biology of vaccination in the elderly. 2013
  Current topics in microbiology and immunology Systems biology of vaccination in the elderly.
• Immunity to viruses: learning from successful human vaccines. 2013
  Immunological reviews Immunity to viruses: learning from successful human vaccines.
• Systems biological approaches to measure and understand vaccine immunity in humans. 2013
  Seminars in immunology Systems biological approaches to measure and understand vaccine immunity in humans.
• Systems vaccinology: learning to compute the behavior of vaccine induced immunity. 2012
  Wiley interdisciplinary reviews. Systems biology and medicine Systems vaccinology: learning to compute the behavior of vaccine induced immunity.
• Repression of bacterial lipoprotein production by Francisella novicida facilitates evasion of innate immune recognition. 2012
  Cellular microbiology Repression of bacterial lipoprotein production by Francisella novicida facilitates evasion of innate immune recognition.
• Systems vaccinology: its promise and challenge for HIV vaccine development. 2012
  Systems biology successfully applied to yellow-fever and influenza vaccines has led to the discovery of signatures that predict vaccine immunogenicity, and promises to advance basic immunology research by providing novel mechanistic insights about immune regulation. However a major challenge of systems vaccinology concerns the analyses and interpretation of the large and noisy data sets generated by high-throughput techniques. Overcoming these issues, we envision that systems vaccinology will have a potential impact on vaccine development, including HIV vaccines. Systems vaccinology: its promise and challenge for HIV vaccine development.
• Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults. 2011
  Journal of Immunology Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults.
• Origins of the Xylella fastidiosa prophage-like regions and their impact in genome differentiation. 2008
  PloS one Origins of the Xylella fastidiosa prophage-like regions and their impact in genome differentiation.
• The iron stimulon of Xylella fastidiosa includes genes for type IV pilus and colicin V-like bacteriocins. 2008
  Journal of bacteriology The iron stimulon of Xylella fastidiosa includes genes for type IV pilus and colicin V-like bacteriocins.
• Conserved tissue expression signatures of intronic noncoding RNAs transcribed from human and mouse loci. 2008
  Genomics Conserved tissue expression signatures of intronic noncoding RNAs transcribed from human and mouse loci.
• Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumors. 2007
  Biochemical and biophysical research communications Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumors.
• Concepts on Microarray Design for Genome and Transcriptome Analyses 2007
  Nucleic Acids Hybridization Modern Applications Concepts on Microarray Design for Genome and Transcriptome Analyses
• Androgen responsive intronic non-coding RNAs. 2007
  BMC biology Androgen responsive intronic non-coding RNAs.
• As antisense RNA gets intronic. 2005
  Omics : a journal of integrative biology As antisense RNA gets intronic.
• RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. 2004
  Biochemical and biophysical research communications RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors.