Network & Precision Medicine
The structure and function of biological systems are determined by a complex network of interactions among cell components. Network medicine offers a toolset for us to systematically explore perturbations in biological networks and to understand how they can spread and affect other cellular processes. In this way, we can have mechanistic insights underlying diseases and phenotypes, evaluate gene function in the context of their molecular interactions, and identify molecular relationships among apparently distinct phenotypes. These tools have also enabled the interpretation of heterogeneity among biological samples, identification of drug targets and drug repurposing as well as biomarker discovery. As our ability to profile biological samples increases, these network-based approaches are fundamental for Precision Medicine.
Lista de serviços
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Gene regulatory and signaling networks exhibit distinct topological distributions of motifs.Gene regulatory and signaling networks exhibit distinct topological distributions of motifs.
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Gene signatures of autopsy lungs from obese patients with COVID-19.Gene signatures of autopsy lungs from obese patients with COVID-19.
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Network Medicine: Methods and ApplicationsNetwork Medicine: Methods and Applications
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ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19.ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19.
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Drug repositioning for psychiatric and neurological disorders through a network medicine approach.Drug repositioning for psychiatric and neurological disorders through a network medicine approach.
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Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes.Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes.
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In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19.In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19.
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The evolution of knowledge on genes associated with human diseasesThe evolution of knowledge on genes associated with human diseases
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Network vaccinology.Network vaccinology.
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Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammationPyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation
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Transcriptome analysis of six tissues obtained post-mortem from sepsis patientsTranscriptome analysis of six tissues obtained post-mortem from sepsis patients
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Gene Signatures of Symptomatic and Asymptomatic Clinical-Immunological Profiles of Human Infection by Leishmania (L.) chagasi in Amazonian BrazilGene Signatures of Symptomatic and Asymptomatic Clinical-Immunological Profiles of Human Infection by Leishmania (L.) chagasi in Amazonian Brazil