CSBL Immunology of Human Diseases

Immunology of Human Diseases - project

Systems Immunology of Human Diseases

With the technological revolutions that occurred in the past decades, we are now able to access and integrate information about all the components within a biological system (e.g., genes, proteins, cells) and use it to compute and predict that system’s behavior. When applied to immunology, systems biology approaches can help us to understand the mechanisms by which pathogens and vaccines stimulate protective immunity. We have several projects on systems immunology that utilize mathematical approaches and computational methods to provide comprehensive and unbiased dissections of the complex interactions between genes and proteins in human diseases.

Lista de serviços

Chapter 15 - Systems Biology of Infectious Diseases and Vaccines
Chapter 15 - Systems Biology of Infectious Diseases and Vaccines
Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms.
Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms.
Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications.
Systems Immunology of Diabetes-Tuberculosis Comorbidity Reveals Signatures of Disease Complications.
Systems Immunology
Systems Immunology
Gene profiling of Chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritis.
Gene profiling of Chikungunya virus arthritis in a mouse model reveals significant overlap with rheumatoid arthritis.
Toward an Integrated View of Operational Tolerance in Human Renal Transplantation: A Systems Biology Perspective.
Toward an Integrated View of Operational Tolerance in Human Renal Transplantation: A Systems Biology Perspective.
Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients
Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients
Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19
Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19
The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age.
The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2-infected patients by sex and age.
Immature neutrophil signature associated with the sexual dimorphism of systemic juvenile idiopathic arthritis.
Immature neutrophil signature associated with the sexual dimorphism of systemic juvenile idiopathic arthritis.
Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria.
Platelet disturbances correlate with endothelial cell activation in uncomplicated Plasmodium vivax malaria.
miRNAs may play a major role in the control of gene expression in key pathobiological processes in Chagas disease cardiomyopathy.
miRNAs may play a major role in the control of gene expression in key pathobiological processes in Chagas disease cardiomyopathy.
Zika virus infection and cytokines.
Zika virus infection and cytokines.
Systems immunology of flavivirus infection.
Systems immunology of flavivirus infection.
Kdm6b Regulates the Generation of Effector CD8 + T Cells by Inducing Chromatin Accessibility in Effector-Associated Genes
Kdm6b Regulates the Generation of Effector CD8 + T Cells by Inducing Chromatin Accessibility in Effector-Associated Genes
Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses.
Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses.
Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate.
Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate.
Severe COVID-19 shares a common neutrophil activation signature with other acute inflammatory states
Severe COVID-19 shares a common neutrophil activation signature with other acute inflammatory states
Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells
Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells
Daily Rhythms of TNFα Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle.
Daily Rhythms of TNFα Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle.
Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells.
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis.
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis.
Systems analysis of subjects acutely infected with the Chikungunya virus.
Systems analysis of subjects acutely infected with the Chikungunya virus.
Molecular alterations in the extracellular matrix in the brains of newborns with congenital Zika syndrome.
Molecular alterations in the extracellular matrix in the brains of newborns with congenital Zika syndrome.
Inflammation induced by influenza virus impairs human innate immune control of pneumococcus.
Inflammation induced by influenza virus impairs human innate immune control of pneumococcus.
Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression
Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression
Increased mTOR Signaling and Impaired Autophagic Flux Are Hallmarks of SARS-CoV-2 Infection.
Increased mTOR Signaling and Impaired Autophagic Flux Are Hallmarks of SARS-CoV-2 Infection.
Chikungunya patient transcriptional signatures faithfully recapitulated in a C57BL/6J mouse model
Chikungunya patient transcriptional signatures faithfully recapitulated in a C57BL/6J mouse model
Imbalanced IL-1B and IL-18 Expression in Sézary Syndrome
Imbalanced IL-1B and IL-18 Expression in Sézary Syndrome
C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps
C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps
Cutting Edge: Polycomb Repressive Complex 1 Subunit Cbx4 Positively Regulates Effector Responses in CD8 T Cells
Cutting Edge: Polycomb Repressive Complex 1 Subunit Cbx4 Positively Regulates Effector Responses in CD8 T Cells
COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis
COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis
Characteristics and anatomic location of PD-1(+)TCF1(+) stem-like CD8 T cells in chronic viral infection and cancer
Characteristics and anatomic location of PD-1(+)TCF1(+) stem-like CD8 T cells in chronic viral infection and cancer
Morphological, cellular, and molecular basis of brain infection in COVID-19 patients
Morphological, cellular, and molecular basis of brain infection in COVID-19 patients

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