MS-Driven Metabolic Alterations Are Recapitulated in iPSC-Derived Astrocytes
Here we describe the metabolic profile of iPSC-derived astrocytes from PwMS and validate this model as a very powerful tool to study disease mechanisms and to perform non-invasive drug targeting assays in vitro. Our findings recapitulate several disease features described in patients and provide new mechanistic insights into the metabolic rewiring of astrocytes in MS, which could be targeted in future therapeutic studies.
Authors
Ghirotto, Bruno; Oliveira, Danyllo F; Cipelli, Marcella; Basso, Paulo J; de Lima, Jean; Breda, Cristiane NS; Ribeiro, Henrique C; Silva, Camille CC; Sertie, Andrea L; Oliveira, Antonio Edson R;
External link
Publication Year
2022
Publication Journal
Annals of Neurology
Associeted Project
Microbiology or Immunology
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