Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination.
The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56 + NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR) + cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR + CD56 dim or cytokine-responsive CD56 bright NK cells. Thus, NK cells may contribute to the early protective efficacy of rVSV-ZEBOV in humans.
Authors
David Pejoski; Casimir de Rham; Paola Martinez-Murillo; Francesco Santoro; Floriane Auderset; Donata Medaglini; Gianni Pozzi; Maria Vono; Paul-Henri Lambert; Angela Huttner; Mariëlle C Haks; Tom H M Ottenhoff; Jean Villard; Claire-Anne Siegrist
External link
Publication Year
2020
Publication Journal
NPJ vaccines
Associeted Project
Microbiology or Immunology
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