Is the gut microbiome key to modulating vaccine efficacy?
A symbiotic relationship with gut microbes is critical for the normal function of human health. Vaccination, however, tips the symbiotic balance slightly in favor of human health. Recent work has shown that gut bacterial residents can have great (positive) influence over vaccine-induced immunity. With an arsenal of modern high-throughput technologies in the hands of microbiologists and immunologists, it is now easier and more cost-effective than ever to characterize and measure the microbiome of vaccinees. Such data will lead to an understanding of how and to what extent gut microbes can impact vaccine efficacy.
Publication Year
2015
Publication Journal
Expert review of vaccines
Associeted Project
Drug repositioning
Lista de serviços
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Gene regulatory and signaling networks exhibit distinct topological distributions of motifs.Gene regulatory and signaling networks exhibit distinct topological distributions of motifs.
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Gene signatures of autopsy lungs from obese patients with COVID-19.Gene signatures of autopsy lungs from obese patients with COVID-19.
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Network Medicine: Methods and ApplicationsNetwork Medicine: Methods and Applications
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ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19.ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19.
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Drug repositioning for psychiatric and neurological disorders through a network medicine approach.Drug repositioning for psychiatric and neurological disorders through a network medicine approach.
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Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes.Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes.
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In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19.In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19.
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The evolution of knowledge on genes associated with human diseasesThe evolution of knowledge on genes associated with human diseases
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Network vaccinology.Network vaccinology.
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Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammationPyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation
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Transcriptome analysis of six tissues obtained post-mortem from sepsis patientsTranscriptome analysis of six tissues obtained post-mortem from sepsis patients
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Gene Signatures of Symptomatic and Asymptomatic Clinical-Immunological Profiles of Human Infection by Leishmania (L.) chagasi in Amazonian BrazilGene Signatures of Symptomatic and Asymptomatic Clinical-Immunological Profiles of Human Infection by Leishmania (L.) chagasi in Amazonian Brazil