Editorial: Systems immunology to advance vaccine development.
The field of systems immunology has emerged as an essential interdisciplinary approach for understanding immune responses on a comprehensive, system-wide level. By integrating high-throughput technologies such as transcriptomics, proteomics, and computational modeling, systems immunology extends beyond traditional research methods. Systems immunology enables researchers to explore the intricate interactions within the immune components and make prediction about vaccine outcomes, accelerating the development of immunizations against pathogens, including rapidly evolving viruses like SARS-CoV-2. The studies in this Research Topic reflects these advancements, offering fresh insights into the molecular and computational aspects of immune system dynamics, which are crucial for improving vaccine efficacy. Our Research Topic has brought together 133 authors worldwide, culminating in 16 articles showcasing cutting-edge research. These contributions cover a range of themes, from immune receptor dynamics and biomarker discovery to computational modeling and predictive analytics in vaccine responses.
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Associeted Project
Systems Immunology of Human Diseases
Lista de serviços
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Gene regulatory and signaling networks exhibit distinct topological distributions of motifs.Gene regulatory and signaling networks exhibit distinct topological distributions of motifs.
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Gene signatures of autopsy lungs from obese patients with COVID-19.Gene signatures of autopsy lungs from obese patients with COVID-19.
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Network Medicine: Methods and ApplicationsNetwork Medicine: Methods and Applications
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ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19.ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19.
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Drug repositioning for psychiatric and neurological disorders through a network medicine approach.Drug repositioning for psychiatric and neurological disorders through a network medicine approach.
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Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes.Linking proteomic alterations in schizophrenia hippocampus to NMDAr hypofunction in human neurons and oligodendrocytes.
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In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19.In-depth analysis of laboratory parameters reveals the interplay between sex, age, and systemic inflammation in individuals with COVID-19.
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The evolution of knowledge on genes associated with human diseasesThe evolution of knowledge on genes associated with human diseases
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Network vaccinology.Network vaccinology.
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Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammationPyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation
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Transcriptome analysis of six tissues obtained post-mortem from sepsis patientsTranscriptome analysis of six tissues obtained post-mortem from sepsis patients
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Gene Signatures of Symptomatic and Asymptomatic Clinical-Immunological Profiles of Human Infection by Leishmania (L.) chagasi in Amazonian BrazilGene Signatures of Symptomatic and Asymptomatic Clinical-Immunological Profiles of Human Infection by Leishmania (L.) chagasi in Amazonian Brazil
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In vitro morphological profiling of T cells predicts clinical response to natalizumab therapy in patients with multiple sclerosis.In vitro morphological profiling of T cells predicts clinical response to natalizumab therapy in patients with multiple sclerosis.
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Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis.Integrative immunology identified interferome signatures in uveitis and systemic disease-associated uveitis.
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Gene regulatory networks analysis for the discovery of prognostic genes in gliomas.Gene regulatory networks analysis for the discovery of prognostic genes in gliomas.
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Revealing shared molecular drivers of brain metastases from distinct primary tumors.Revealing shared molecular drivers of brain metastases from distinct primary tumors.