“Given the functional interdependencies between the molecular components in a human cell, a disease is rarely a consequence of an abnormality in a single gene, but reflects the perturbations of the complex intracellular and intercellular network that links tissue and organ systems. The emerging tools of network medicine offer a platform to explore systematically not only the molecular complexity of a particular disease, leading to the identification of disease modules and pathways, but also the molecular relationships among apparently distinct (patho)phenotypes. Advances in this direction are essential for identifying new disease genes, for uncovering the biological significance of disease-associated mutations identified by genome-wide association studies and full-genome sequencing, and for identifying drug targets and biomarkers for complex diseases.”
Barabási ( Nat Rev Genet. 2011 Jan;12(1):56-68)

We have been using Network Medicine to study a broad range of infectious diseases (Chikungunya, Zika, Dengue, Yellow Fever, Tuberculosis) and inflammatory diseases (arthritis, IBD, lupus, sepsis, multiple sclerosis, among others). Also, we are applying the principles of Network Medicine for drug repositioning.

In this FB post you can see how diseases were studied in the past 70 years. We have analyzed 29,000,000 articles and over 250GB of data: