CSBL Systems Vaccinology

Systems Vaccinology - project

Systems Vaccinology

Vaccination is one of the greatest triumphs of modern medicine, yet we remain largely ignorant of the mechanisms by which successful vaccines stimulate protective immunity. The structure and function of the immune system is governed by complex networks of interactions between cells and molecular components. Vaccination perturbs these networks, triggering specific pathways to induce cellular and humoral immunity. Systems vaccinology studies have generated vast data sets describing the genes related to vaccination, motivating the use of new approaches to identify patterns within the data.

Lista de serviços

Systems vaccinology: its promise and challenge for HIV vaccine development.
Systems vaccinology: its promise and challenge for HIV vaccine development.
Systems vaccinology: learning to compute the behavior of vaccine induced immunity.
Systems vaccinology: learning to compute the behavior of vaccine induced immunity.
Systems biology of vaccination in the elderly.
Systems biology of vaccination in the elderly.
Immunity to viruses: learning from successful human vaccines.
Immunity to viruses: learning from successful human vaccines.
Systems biological approaches to measure and understand vaccine immunity in humans.
Systems biological approaches to measure and understand vaccine immunity in humans.
Gene signatures related to B-cell proliferation predict influenza vaccine-induced antibody response.
Gene signatures related to B-cell proliferation predict influenza vaccine-induced antibody response.
Vaccinology in the era of high-throughput biology.
Vaccinology in the era of high-throughput biology.
Systems vaccinology: Enabling rational vaccine design with systems biological approaches.
Systems vaccinology: Enabling rational vaccine design with systems biological approaches.
Systems Vaccinology Applied to DNA Vaccines: Perspective and Challenges.
Systems Vaccinology Applied to DNA Vaccines: Perspective and Challenges.
Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques.
Adjuvanting a Simian Immunodeficiency Virus Vaccine with Toll-Like Receptor Ligands Encapsulated in Nanoparticles Induces Persistent Antibody Responses and Enhanced Protection in TRIM5α Restrictive Macaques.
Methods for predicting vaccine immunogenicity and reactogenicity.
Methods for predicting vaccine immunogenicity and reactogenicity.
Antigenicity prediction and vaccine recommendation of human influenza virus A (H3N2) using convolutional neural networks.
Antigenicity prediction and vaccine recommendation of human influenza virus A (H3N2) using convolutional neural networks.
Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine.
Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine.
Human Transcriptomic Response to the VSV-Vectored Ebola Vaccine.
Human Transcriptomic Response to the VSV-Vectored Ebola Vaccine.
Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever.
Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever.
Systems Biology Analysis of the Radiation-Attenuated Schistosome Vaccine Reveals a Role for Growth Factors in Protection and Hemostasis Inhibition in Parasite Survival.
Systems Biology Analysis of the Radiation-Attenuated Schistosome Vaccine Reveals a Role for Growth Factors in Protection and Hemostasis Inhibition in Parasite Survival.
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination
Molecular alterations in human milk in simulated maternal nasal mucosal infection with live attenuated influenza vaccination
Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood.
Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood.
Systems analysis of protective immune responses to RTS,S malaria vaccination in humans.
Systems analysis of protective immune responses to RTS,S malaria vaccination in humans.
Systems vaccinology.
Systems vaccinology.
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans.
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans.
Systems biology of vaccination for seasonal influenza in humans.
Systems biology of vaccination for seasonal influenza in humans.
Prior upregulation of interferon pathways in the nasopharynx impacts viral shedding following live attenuated influenza vaccine challenge in children
Prior upregulation of interferon pathways in the nasopharynx impacts viral shedding following live attenuated influenza vaccine challenge in children
Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures.
Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures.
Molecular signatures of antibody responses derived from a systems biology study of five human vaccines.
Molecular signatures of antibody responses derived from a systems biology study of five human vaccines.
Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination.
Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination.
Metabolic Phenotypes of Response to Vaccination in Humans.
Metabolic Phenotypes of Response to Vaccination in Humans.
Hidden in plain sight: uncovering the role of CREB1 in HIV-1 vaccine-induced immunity
Hidden in plain sight: uncovering the role of CREB1 in HIV-1 vaccine-induced immunity
Transcriptomic signatures induced by the Ebola virus vaccine rVSV-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study
Transcriptomic signatures induced by the Ebola virus vaccine rVSV-ZEBOV-GP in adult cohorts in Europe, Africa, and North America: a molecular biomarker study
Baseline gene signatures of reactogenicity to Ebola vaccination: a machine learning approach across multiple cohorts
Baseline gene signatures of reactogenicity to Ebola vaccination: a machine learning approach across multiple cohorts
Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSVΔG-ZEBOV-GP
Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSVΔG-ZEBOV-GP

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