CSBL Microbiology or Immunology

Microbiology or Immunology - project

Microbiology or Immunology

Immunology is the study of the immune system and is a very important branch of the medical and biological sciences. The immune system protects us from infection through various lines of defence. If the immune system is not functioning as it should, it can result in disease, such as autoimmunity, allergy and cancer. Microbiology is the study of microscopic organisms, such as bacteria, viruses, archaea, fungi and protozoa. Our laboratory has several projects and publications related to both microbiology or immunology.

Lista de serviços

Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults.
Phenotype, function, and gene expression profiles of programmed death-1(hi) CD8 T cells in healthy human adults.
Repression of bacterial lipoprotein production by Francisella novicida facilitates evasion of innate immune recognition.
Repression of bacterial lipoprotein production by Francisella novicida facilitates evasion of innate immune recognition.
CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis.
CCR2 deficiency promotes exacerbated chronic erosive neutrophil-dominated chikungunya virus arthritis.
Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection.
Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection.
Myeloperoxidase in human peripheral blood lymphocytes: Production and subcellular localization.
Myeloperoxidase in human peripheral blood lymphocytes: Production and subcellular localization.
Analysis of LexA binding sites and transcriptomics in response to genotoxic stress in Leptospira interrogans.
Analysis of LexA binding sites and transcriptomics in response to genotoxic stress in Leptospira interrogans.
SerpinB2 Deficiency Results in a Stratum Corneum Defect and Increased Sensitivity to Topically Applied Inflammatory Agents.
SerpinB2 Deficiency Results in a Stratum Corneum Defect and Increased Sensitivity to Topically Applied Inflammatory Agents.
Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration.
Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration.
N-Methyl-d-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection
N-Methyl-d-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection
Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular Dysfunction.
Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular Dysfunction.
In situ Immune Signatures and Microbial Load at the Nasopharyngeal Interface in Children With Acute Respiratory Infection
In situ Immune Signatures and Microbial Load at the Nasopharyngeal Interface in Children With Acute Respiratory Infection
TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis.
TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis.
Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2).
Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2).
Molecular degree of perturbation of plasma inflammatory markers associated with tuberculosis reveals distinct disease profiles between Indian and Chinese populations.
Molecular degree of perturbation of plasma inflammatory markers associated with tuberculosis reveals distinct disease profiles between Indian and Chinese populations.
SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages.
SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages.
Biological sex influences antibody responses to routine vaccinations in the first year of life.
Biological sex influences antibody responses to routine vaccinations in the first year of life.
Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation.
Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation.
Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression, Shedding, and Antibody-dependent Enhancement (ADE).
Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression, Shedding, and Antibody-dependent Enhancement (ADE).
Variants in the Kisspeptin-GnRH Pathway Modulate the Hormonal Profile and Reproductive Outcomes.
Variants in the Kisspeptin-GnRH Pathway Modulate the Hormonal Profile and Reproductive Outcomes.
Hydroquinone exposure alters the morphology of lymphoid organs in vaccinated C57Bl/6 mice.
Hydroquinone exposure alters the morphology of lymphoid organs in vaccinated C57Bl/6 mice.
P2x7 Receptor Signaling Blockade Reduces Lung Inflammation and Necrosis During Severe Experimental Tuberculosis.
P2x7 Receptor Signaling Blockade Reduces Lung Inflammation and Necrosis During Severe Experimental Tuberculosis.
Neuroinflammation at single cell level: What is new?
Neuroinflammation at single cell level: What is new?
Whole-Genome Sequencing of Leishmania infantum chagasi Isolates from Honduras and Brazil
Whole-Genome Sequencing of Leishmania infantum chagasi Isolates from Honduras and Brazil
Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses
Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses
Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination.
Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination.
An Experimental DUAL Model of Advanced Liver Damage
An Experimental DUAL Model of Advanced Liver Damage
Colorimetric RT-LAMP SARS-CoV-2 diagnostic sensitivity relies on color interpretation and viral load
Colorimetric RT-LAMP SARS-CoV-2 diagnostic sensitivity relies on color interpretation and viral load
Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates.
Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates.
Lower temperatures reduce type I interferon activity and promote alphaviral arthritis.
Lower temperatures reduce type I interferon activity and promote alphaviral arthritis.
Acute Zika Virus Infection in an Endemic Area Shows Modest Proinflammatory Systemic Immunoactivation and Cytokine-Symptom Associations.
Acute Zika Virus Infection in an Endemic Area Shows Modest Proinflammatory Systemic Immunoactivation and Cytokine-Symptom Associations.
Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation.
Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation.
Uptake of Plasmodium chabaudi hemozoin drives Kupffer cell death and fuels superinfections
Uptake of Plasmodium chabaudi hemozoin drives Kupffer cell death and fuels superinfections
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19
Flavivirus-Mediating B Cell Differentiation Into Antibody-Secreting Cells in Humans Is Associated With the Activation of the Tryptophan Metabolism.
Flavivirus-Mediating B Cell Differentiation Into Antibody-Secreting Cells in Humans Is Associated With the Activation of the Tryptophan Metabolism.
Acute Inflammation Is a Predisposing Factor for Weight Gain and Insulin Resistance
Acute Inflammation Is a Predisposing Factor for Weight Gain and Insulin Resistance
Initial viral load determines the magnitude of the human CD8 T cell response to yellow fever vaccination.
Initial viral load determines the magnitude of the human CD8 T cell response to yellow fever vaccination.
SARS-CoV-2 infected children form early immune memory responses dominated by nucleocapsid-specific CD8+ T cells and antibodies
SARS-CoV-2 infected children form early immune memory responses dominated by nucleocapsid-specific CD8+ T cells and antibodies
Differentiation of Memory CD8 T Cells Unravel Gene Expression Pattern Common to Effector and Memory Precursors
Differentiation of Memory CD8 T Cells Unravel Gene Expression Pattern Common to Effector and Memory Precursors
Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection.
Crucial role for T cell-intrinsic IL-18R-MyD88 signaling in cognate immune response to intracellular parasite infection.
Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis.
Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis.
Aryl hydrocarbon receptor (AhR) activation contributes to high fat diet induced vascular dysfunction
Aryl hydrocarbon receptor (AhR) activation contributes to high fat diet induced vascular dysfunction
Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression
Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression
MS-Driven Metabolic Alterations Are Recapitulated in iPSC-Derived Astrocytes
MS-Driven Metabolic Alterations Are Recapitulated in iPSC-Derived Astrocytes
Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study.
Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study.
PD-1/PD-L1 inhibition enhances chemotherapy-induced neuropathic pain by suppressing neuroimmune antinociceptive signaling
PD-1/PD-L1 inhibition enhances chemotherapy-induced neuropathic pain by suppressing neuroimmune antinociceptive signaling
Knockout of cellular prion protein in glioblastoma affects the expression of Wnt signaling genes
Knockout of cellular prion protein in glioblastoma affects the expression of Wnt signaling genes
PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical beta-coronavirus disease
PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical beta-coronavirus disease
The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.
The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.
Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity.
Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity.
TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination.
TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination.
Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine.
Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine.
Programming the magnitude and persistence of antibody responses with innate immunity.
Programming the magnitude and persistence of antibody responses with innate immunity.
Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.
Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation.
Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination.
Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination.
Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation.
Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation.
The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation.
The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation.
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy.
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy.
Sepsis expands a CD39(+) plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity
Sepsis expands a CD39(+) plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity
Antibody responses to recombinant vesicular stomatitis virus-Zaire Ebolavirus vaccination for Ebola virus disease across doses and continents: 5-year durability
Antibody responses to recombinant vesicular stomatitis virus-Zaire Ebolavirus vaccination for Ebola virus disease across doses and continents: 5-year durability
Combining IP(3) affinity chromatography and bioinformatics reveals a novel protein-IP(3) binding site on Plasmodium falciparum MDR1 transporter.
Combining IP(3) affinity chromatography and bioinformatics reveals a novel protein-IP(3) binding site on Plasmodium falciparum MDR1 transporter.
SARS-CoV-2 uses CD4 to infect T helper lymphocytes
SARS-CoV-2 uses CD4 to infect T helper lymphocytes
Expression of HMGCS2 in intestinal epithelial cells is downregulated in inflammatory bowel disease associated with endoplasmic reticulum stress
Expression of HMGCS2 in intestinal epithelial cells is downregulated in inflammatory bowel disease associated with endoplasmic reticulum stress
Immunodominant antibody responses directed to SARS-CoV-2 hotspot mutation sites and risk of immune escape
Immunodominant antibody responses directed to SARS-CoV-2 hotspot mutation sites and risk of immune escape
Novel therapeutic avenues for the study of chronic liver disease and regeneration: The foundation of the Iberoamerican Consortium for the study of liver Cirrhosis
Novel therapeutic avenues for the study of chronic liver disease and regeneration: The foundation of the Iberoamerican Consortium for the study of liver Cirrhosis
Identification of pathogenic variants in the Brazilian cohort with Familial hypercholesterolemia using exon-targeted gene sequencing
Identification of pathogenic variants in the Brazilian cohort with Familial hypercholesterolemia using exon-targeted gene sequencing
CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation
CASP4/11 Contributes to NLRP3 Activation and COVID-19 Exacerbation
S100A9 Drives the Chronification of Psoriasiform Inflammation by Inducing IL-23/Type 3 Immunity
S100A9 Drives the Chronification of Psoriasiform Inflammation by Inducing IL-23/Type 3 Immunity
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort
Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort

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